Journal of General Virology

Fig. 3. Multiple sequence alignment of conserved regions in replicase polyproteins of picorna-like viruses. BQCV, SBV and APV represent picorna-like insect-infecting viruses with different genome structures. In addition, single members from each of the picorna-like virus families Picornaviridae (PV), Caliciviridae (FCV), Comoviridae (CPMV) and Sequiviridae (PYFV) have been included. The numbers on the left of each sequence indicate amino acid positions relative to the corresponding replicase protein. Numbers within sequences represent omitted amino acids. Alignments represent putative helicase (a), protease (b) and RdRp (c) domains. Conserved regions within helicases corresponding to those recognized by Koonin & Dolja (1993) are labelled Hel-A, Hel-B and Hel-C. Asterisks indicate amino acids that may be essential for protease activity. Conserved regions in RdRps corresponding to those recognized by Koonin & Dolja (1993) are labelled 1–8.

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