Journal of General Virology

Fig. 4. Histology of thoracic spinal cords (A–D) and sciatic nerves (E, F), from a terminally sick tga20 mouse compared to a mock injected tga20 mouse. In both mice the injection was i.n. Strong gliosis (D) and spongiosis (B) are visible in the spinal cord of the terminally sick mouse. (A) and (B) Haematoxylin–eosin stain; (C)–(D) GFAP immunohistochemistry. Original magnifications, x100. (E)–(F) Semi-thin sections of injected sciatic nerves from a mock injected tga20 mouse (E) and terminally sick tga20 mouse (F). Axonal degeneration is obvious in (F): single axons undergoing Wallerian degeneration are indicated by an arrow. Original magnification, x260.

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