Journal of General Virology

Herpesvirus saimiri protein StpB associates with cellular Src

Simon Hör,¹ Armin Ensser,¹ Christine Reiss,¹ Kurt Ballmer-Hofer² and Brigitte Biesinger¹

¹ Institut für Klinische und Molekulare Virologie, Universität Erlangen-Nürnberg, Schloßgarten 4, D-91054 Erlangen, Germany
² Institute for Radiobiology at the Paul Scherrer Institute, CH-5232 Villigen-PSI, Switzerland

Subgroup B isolates of Herpesvirus saimiri are less efficient in T lymphocyte transformation when compared with subgroups A or C. Here it is shown that subgroup B strain SMHI encodes a protein, StpB, at a position equivalent to those of the ORFs for the saimiri transforming proteins (Stp) of subgroups A and C. StpB shares little similarity with StpA or StpC, but interacts with the SH2 domain of cellular Src, as does StpA. Thus, factors other than c-Src binding determine the efficiency of primary T cell transformation by Herpesvirus saimiri.

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© 2000 SGM

This article is now available in the February 2001 print issue of JGV (vol. 82, 339–344). The complete issue of the journal may be seen in electronic form on JGV Online.