Journal of General Virology

Fig. 1. Primary structure of HVS B-SMHI sequences relevant to transformation. (A) Dot plot comparison of the left-terminal nucleotide sequences of HVS B-SMHI and A-11 (GCG programs COMPARE and DOTPLOT; window 32, stringency 24). ORFs and HSUR sequences of HVS B-SMHI are indicated above the dot matrix. DHFR, Dihydrofolate reductase. (B) Amino acid comparison of StpA and StpB. Sequences are aligned manually to produce overlaps for conserved patterns, namely GX₁X₂ motifs (open boxes), potential TRAF-binding sites (bold), the SH2-binding consensus YAEV/I (black boxes) and hydrophobic C termini (underlined). Arrowheads indicate the positions of tyrosine residues mutated to phenylalanine (see Fig. 2).

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