Journal of General Virology

Fig. 2. Specific antibody response to FMDV after DNA vaccination. Results are presented from experiment A, in which animal groups were housed separately. This experiment employed a course of three injections of plasmid at intervals of 3–4 weeks (indicated by arrows). The challenge virus was given 2 weeks after the last injection and the different animal groups were subsequently housed in separate boxes. Sera from immunized animals were sampled regularly and tested for antibodies at 1:80 dilution. Specific antibody response to whole FMDV was measured by capture ELISA (see Methods). The results are presented for individual animals as A₄₉₂. A group of pigs vaccinated with conventional vaccine was used as positive controls and animals vaccinated with pcDNA3/GM-CSF alone were used as negative controls.

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