Journal of General Virology

Fig. 2. Schematic representation of viruses produced by site-directed mutagenesis of the infectious clone, pGGVs. The flavivirus genome with the open reading frame encoding the proteins from C to NS5 is shown at the top. The 5´UTR and 3´UTR are shown as solid bars. Arrows show the positions of four amino acids and one nucleotide substitution between the Vs parental virus and the infectious clone, pGGVs. Mutants are depicted as solid lines with the names of the viruses on the right. Each substitution is specified as a letter with numbers showing the position (arrows) on the virus polyprotein (for amino acids) or genome (for nucleotides within the 3´UTR).

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