Journal of General Virology

Fig. 1. B lymphocyte-derived cytokines are critical for maintaining the maturation of FDCs. These include membrane lymphotoxin ₁/₂, which signals exclusively through the lymphotoxin receptor, and soluble tumour necrosis factor- (TNF), which signals through the TNF-receptor 1 (TNF-R1). Both receptors are expressed on the FDC and/or its precursor cell. In the absence of either of the above cytokines or their corresponding receptors, FDCs do not differentiate.

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