Journal of General Virology

Fig. 3. Topology of the TM domains of HCV envelope proteins before and after signal sequence cleavage. The topology of p7 is putative. The sequences of the TM domains of HCV glycoproteins of the H strain are presented at the bottom of the figure. The numbers above the sequences of E1 and E2 indicate the positions of the N- and C-terminal limits of the TM domains within the HCV polyprotein. Charged residues present in the middle of the TM domains of E1 and E2 are in bold. Arrows indicate the positions of inserted alanine residues that disrupt E1E2 heterodimerization (Op De Beeck et al., 2000). The two hydrophobic segments in the TM domains of E1 and E2 are underlined. The C-terminal hydrophobic segments of E1 and E2, including the positively charged residue immediately upstream, are signal sequences.

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