(NT01) Metals and Microbes
Monday 6 (AM), Tuesday 7 (AM), Wednesday 8 (AM) & Thursday 9 (AM) September 2010
Organizers: Jen Cavet — email Jennifer.s.cavet@manchester.ac.uk
Nigel Robinson — email N.J.Robinson@newcastle.ac.uk
Almost half of all enzymes require a particular metal to function. Microbes have evolved elaborate mechanisms to scavenge for sufficient metal atoms to meet their needs and to adjust their needs to match supply. Metal sensors, transporters and stores have often been associated with metal-resistance, but it is emerging that they perform a broader role in microbial physiology; for example in helping proteins to acquire the correct metals. Metal-availability has altered over geological time and varies between habitats resulting in a diversity of microbial metal homeostatic systems. Presented in four sessions, this symposium will focus on these systems and will consider the importance of metals in microbial adaptation and in pathogenicity.
For a printable Session Outline click here
Monday 6 September 2010 – NT01 |
Chair |
Sabeeha Merchant
UCLA, USA |
08:30 |
Uptake and reduction of iron in Escherichia coli
Simon Andrews
University of Reading, UK |
09:00 |
Comparative Genomics of Trace Element Utilization
Vadim Gladyshev
Harvard Medical School, USA |
09:30 |
Ancient and modern environmental pressures shape biological metal utilization
Chris Dupont
J. Craig Venter Institute, USA |
10:00 |
Refreshments |
10:30 |
Redox-dependent copper trafficking: from eukaryotes to bacteria
Simone Ciofi-Baffoni
University of Florence, Italy |
11:00 |
Maturation of multicopper oxidases in the Golgi - the chloride connection
Blanche Schwappach
University of Manchester |
11:30 |
The Role of Mzm1 in maintenance of mitochondrial zinc and Complex III Biogenesis
Dennis Winge
University of Utah, USA |
12:00 |
Lunch |
Tuesday 7 September 2010 – NT01 |
Chair |
Nigel Brown
University of Edinburgh, UK |
08:30 |
Don't shoot the messenger! Metal compounds as bearers and targets of carbon monoxide
Robert Poole
University of Sheffield, UK |
09:00 |
Metal induced oxidative stress and iron-sulphur proteins in yeast
Simon Avery
University of Nottingham, UK |
09:30 |
Oxidative stress and metalloenzymes
Jim Imlay
University of Illinois at Urbana-Champaign, USA |
10:00 |
Refreshments |
10:30 |
Iron and copper acquisition in the fungal pathogen Candida albicans: an intimate partnership
Annette Cashmore
University of Leicester, UK |
11:00 |
Nickel, iron and urease: the acid-resistance triangle of pathogenic Helicobacter species
Arnoud van Vliet
Institute of Food Research, Norwich UK |
11:30 |
Interplay between manganese and iron during pneumococcal pathogenesis
Alistair McEwan
The University of Queensland, Australia |
12:10 |
HOT TOPIC LECTURE
Building a cell controlled by a synthetic genome
Clyde Hutchison (The J. Craig Venter Institute, USA)
Business School South - Hall B52 |
13:00 |
Annual General Meeting of the Society for General Microbiology
Business School South, Floor B (First Floor), Hall B52 |
13:00 |
Lunch |
Wednesday 8 September 2010 – NT01 |
Chair |
John Helmann
Cornell University, USA |
08:30 |
Antimicrobial metals – back to the future?
Jon Hobman
University of Nottingham, UK |
09:00 |
Structure and function of Fur proteins from M. tuberculosis
Ehmke Pohl
University of Durham, UK |
09:30 |
Metal Ion Homeostasis: a virulence determinant of streptococci?
Nicholas Jakubovics
University of Newcastle, UK |
10:00 |
Refreshments |
10:30 |
Mechanisms of nickel recognition in transport and regulation
Peter Chivers
Washington University in St. Louis, USA |
11:00 |
Transition metal homeostasis in Cupriavidus metallidurans CH34: systematic deletion analysis to complete the inventory
Dietrich Nies
Martin-Luther-University, Germany |
11:30 |
The role of chelatases in tetrapyrrole biosynthesis
Martin Warren
University of Kent, UK |
12:10 |
PETER WILDY PRIZE FOR MICROBIOLOGY EDUCATION
How the mushroom got its spots and other stories
Sue Assinder (University of Liverpool)
Business School South - Hall B52 |
13:00 |
Lunch |
Thursday 9 September 2010 – NT01 |
Chair |
Dennis Winge
University of Utah, USA |
08:30 |
Defense against copper toxicity by Lactococcus lactis
Marc Solioz
University of Berne, Switzerland |
09:00 |
The complexities of bacterial copper detoxification proteins
Nick Le Brun
University of East Anglia, UK |
09:30 |
Nickel homeostasis in the pathogenic yeast Cryptococcus neoformans
Julian Rutherford
University of Newcastle, UK |
10:00 |
Refreshments |
10:30 |
Iron and Zinc homeostasis in Bacillus subtilis
John Helmann
Cornell University, USA |
11:00 |
Iron Conservation by Reduction of Metalloenzyme Inventories in the Marine Diazotroph Crocosphaera watsonii
Mak Saito
Woods Hole Oceanographic Institution, USA |
11:30 |
Oxidative stress responses in iron-limited Chlamydomanas
Sabeeha Merchant
UCLA, USA |
12:00 |
Lunch |
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