I am somewhat in awe of scientists that can rise to the challenge of authoring such mighty textbooks. Leaving aside the breadth and depth of knowledge required, where did these three find the time, enthusiasm and discipline to produce nearly 1,000 pages of text with over 700 figures and tables? Furthermore, this is a no turgid tome, but a delightfully easy read that takes the reader through the many facets of molecular biotechnology - from the basics of DNA analysis and manipulation, to the ever-expanding areas in which the technology is being applied using microbes, animal and plants. For such a fast-moving field, the authors have done a tremendous job at ensuring that the 4th edition is as current as possible, and each topic is carefully and clearly explained with simple figures and key examples from the literature. Inevitably, there are some topics that have been overlooked (or perhaps kept for the even weightier volume that will be the 5th edition?). For example, there is no discussion of synthetic biology, or the use of engineered microbes in the production of biofuels - two hot areas at present. And my own pet gripe; no mention of the genetic manipulation of algae and their biotech applications. Such minor criticisms aside, this is a book that will be an invaluable core text for both undergraduate and graduate students studying biotechnology or related subjects.