Systems biology probably has almost as many definitions as practitioners. This volume considers systems biology in the broadest terms: the integration of experimental and mathematical approaches to biological systems with the aim of gaining both predictive and explanatory power. Therefore, systems biology is an approach that can potentially be applied to any field of modern biology, from an individual biochemical pathway to a whole ecosystem. Thus the challenge for this volume is the breadth of the field. Individual chapters describe particular biological systems, with the majority dealing with mathematical modelling approaches. In addition there are two chapters detailing experimental approaches at the cellular level.

Predominantly, the methods are clearly explained and well-illustrated, although some may be inaccessible to the non-specialist. Several chapters include lengthy sections of code and this volume would have therefore benefited from a companion website. In summary, the diversity of topics covered and the range of styles employed mean that only certain chapters are likely to be of value to individual biologists. Therefore, this volume will generally be of most value as an institutional purchase.